3315: What on Flat Earth? w/ Brent Terhune

[Apia resurrected]

Originally Posted by Keith

Anyone else hate-watch/listen to anything specific?

No, it’s too annoying for me and I’m too passionate to do it.
When I hate something it’s real hate and I must stay away.

[ahungryninja]

Really needed an option for liking talking to ONE of my parents

[Apia resurrected]

Originally Posted by ahungryninja

Really needed an option for liking talking to ONE of my parents

Science would say that’s a yes.
Parents are 2 people. You like one, you like 50% of the group.

Unless the question would be, do you enjoy talking to all your parents.

Apia
Science Fan.

[Lanfear]

Originally Posted by ahungryninja

Really needed an option for liking talking to ONE of my parents

YES!

Originally Posted by Apia resurrected

Science would say that’s a yes.
Parents are 2 people. You like one, you like 50% of the group.

Unless the question would be, do you enjoy talking to all your parents.

Apia
Science Fan.

No! If something is terrible 50% of the time that's a No. If 50% of patients have severe side effects from medicine that's not a successful trial? Please explain.

I like talking to my dad he is awesome always has been. My mom? Not so much.
Unfortunately they are a package deal so I rarely talk to them and usually don't enjoy it because any fun WhatsApp banter with dad is immediately killed by a mom negativity.

[Apia resurrected]

Originally Posted by Lanfear

YES!



No! If something is terrible 50% of the time that's a No. If 50% of patients have severe side effects from medicine that's not a successful trial? Please explain.
.

Depends always on the primary end point of the trial, and this point is determined before the trial.

Side effects are determined on healthy individuals before it comes to the question if the medicine is really helping or not in sick people.
These are phase 1 studies.

So basically if 50% of healthy individuals had terrible side effects, there would be no phase 2 or 3 study to see if the medicine helps, the drug would be cancelled.

[shoebootie]

Originally Posted by Joshua

As a parent, I always start feeling really bad for Chemda’s mother. I think “oh if that were me and I was trying to reconnect I’d be so heartbroken.” But then I remember that there’s no way I’d not speak to my child for four fucking years and I don’t feel so bad anymore.

I feel the same way, both as a parent and someone who's toxic mother (when she was alive) lead me to distance myself for my own sanity. I can see both sides of this in a sense, and neither of them feel good. The more I identify with this as a mother, the more angry and hurt I feel thinking about how a parent could ever treat their child this way in the past.

She connected with you, maybe she's doing OMAT and this was her sixty seconds. She couldn't go past that minute to explain more on why she was so fucking shitty to you.

[Lanfear]

Originally Posted by Apia resurrected

Depends always on the primary end point of the trial, and this point is determined before the trial.

Side effects are determined on healthy individuals before it comes to the question if the medicine is really helping or not in sick people.
These are phase 1 studies.

So basically if 50% of healthy individuals had terrible side effects, there would be no phase 2 or 3 study to see if the medicine helps, the drug would be cancelled.

Sooooooo

You agree with me that it's a No? But voted yes anyway?

Or are you saying that as adults we have grown past the phase 1 and now just need to accept the toxic abuse because we didn't say no as kids?

[Lanfear]

Originally Posted by Apia resurrected

Depends always on the primary end point of the trial, and this point is determined before the trial.

Side effects are determined on healthy individuals before it comes to the question if the medicine is really helping or not in sick people.
These are phase 1 studies.

So basically if 50% of healthy individuals had terrible side effects, there would be no phase 2 or 3 study to see if the medicine helps, the drug would be cancelled.

Also I just read that again

Are you trying to say that medicine is tested on healthy people?
And if it doesn't harm the healthy ones too much the people it actually is meant to help aren't relevant?

Herr im Himmel was soll der Scheiß? Reiß dich zusammen.

[Apia resurrected]

Originally Posted by Lanfear

Sooooooo

You agree with me that it's a No? But voted yes anyway?

Or are you saying that as adults we have grown past the phase 1 and now just need to accept the toxic abuse because we didn't say no as kids?

My parents both behave in the last years and have even apologized for not great behavior in the past.
They are both pretty good actually, I must admit even if it’s hard to admit. I want to be annoyed but there’s no real reason.

[Apia resurrected]

Originally Posted by Lanfear

Also I just read that again

Are you trying to say that medicine is tested on healthy people?
And if it doesn't harm the healthy ones too much the people it actually is meant to help aren't relevant?

Herr im Himmel was soll der Scheiß? Reiß dich zusammen.

I didn’t make up the protocols for drug testing. I’m not that powerful. That’s phase 1 of clinical trials.
I don’t know why you are mad at me?

Phase I Dose-ranging on healthy volunteers for safety Often subtherapeutic, but with ascending doses Clinical researcher 20–100 normal healthy volunteers (or cancer patients for cancer drugs) Approx. 70% Determines whether drug is safe to check



https://en.wikipedia.org/wiki/Phases...nical_research

Phase 1 is the start, and if the drug isn’t harmful you can test further if it works on sick people.
If the drug is harmful in phase 1 it’s over.