Brianisinyou - Adventures in Hollywood. Really funny.
Common Sense with Dan Carlin - Political stuff. Interesting perspective.
NLO - Started listening because of the Keith/Patrick drama. Ended up liking their show too.
Webcomics Weekly- Podcast about making webcomics.
This American Life - Really quirky stories from around the country.
The Jay and Jack Show - It's usually a LOST podcast, but over the show's hiatus they like to ramble.
NPR: Science Friday - I like to learn new things in the science world.
Apt209 (self promotion) - A podcast that my friend Kelly and I do. We talk about our week and things in the news. Popculture stuff.